USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: TADBP_HUMAN USC-OGP 2-DE database:  TADBP_HUMAN TADBP_HUMAN General information about the entry View entry in simple text format Entry name TADBP_HUMAN Primary accession number Q13148 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=TAR DNA-binding protein 43; Short=TDP-43;. Gene name Name=TARDBP Synonyms=TDP43 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1184: pI=5.92; Mw=43904 Cross-references UniProtKB/Swiss-Prot Q13148; TADBP_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name TADBP_HUMAN Primary accession number Q13148 Secondary accession number(s) A4GUK4 A4GUK5 A4GUK6 B2R629 B4DJ45 E2PU12 Q53H27 Q6FI92 Q96DJ0 Sequence was last modified on  November 1, 1996 (version 1) Annotations were last modified on  March 15, 2017 (version 183) Name and origin of the protein Description RecName: Full=TAR DNA-binding protein 43; Short=TDP-43; Gene name Name=TARDBP Synonyms=TDP43 Encoded on Name=TARDBP; Synonyms=TDP43 Keywords 3D-structure; Alternative splicing; Amyotrophic lateral sclerosis; Complete proteome; Direct protein sequencing; Disease mutation; DNA-binding; Isopeptide bond; Methylation; mRNA processing; mRNA splicing; Neurodegeneration; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Repressor; RNA-binding; Transcription; Transcription regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL U23731; AAA70033.1; -; mRNA EMBL EF434181; ABO32290.1; ALT_SEQ; mRNA EMBL EF434182; ABO32291.1; -; mRNA EMBL EF434183; ABO32292.1; ALT_SEQ; mRNA EMBL AK295920; BAG58707.1; -; mRNA EMBL AK312416; BAG35326.1; -; mRNA EMBL CR533534; CAG38565.1; -; mRNA EMBL AK222754; BAD96474.1; -; mRNA EMBL AL050265; CAB43367.1; -; mRNA EMBL AL109811; CAI22098.1; -; Genomic_DNA EMBL CH471130; EAW71670.1; -; Genomic_DNA EMBL BC071657; AAH71657.1; -; mRNA EMBL BC095435; AAH95435.1; -; mRNA CCDS CCDS122.1; -. [Q13148-1]; . PIR I38977; I38977; . RefSeq NP_031401.1; NM_007375.3. [Q13148-1]; . RefSeq XP_016856352.1; XM_017000863.1. [Q13148-1]; . RefSeq XP_016856353.1; XM_017000864.1. [Q13148-1]; . RefSeq XP_016856354.1; XM_017000865.1. [Q13148-1]; . RefSeq XP_016856355.1; XM_017000866.1. [Q13148-1]; . RefSeq XP_016856356.1; XM_017000867.1. [Q13148-1]; . RefSeq XP_016856357.1; XM_017000868.1. [Q13148-1]; . UniGene Hs.300624; -; . PDB 1WF0; NMR; -; A=193-267 PDB 2CQG; NMR; -; A=96-185 PDB 2N2C; NMR; -; A=307-349 PDB 2N3X; NMR; -; A=311-360 PDB 2N4G; NMR; -; A=311-360 PDB 2N4H; NMR; -; A=311-360 PDB 2N4P; NMR; -; A=1-77 PDB 4BS2; NMR; -; A=102-269 PDB 4IUF; X-ray; 2.75 A; A=103-179 PDB 4Y00; X-ray; 3.00 A; A/B/C/D=101-191 PDB 4Y0F; X-ray; 2.65 A; A/B=101-191 PDBsum 1WF0; -; . PDBsum 2CQG; -; . PDBsum 2N2C; -; . PDBsum 2N3X; -; . PDBsum 2N4G; -; . PDBsum 2N4H; -; . PDBsum 2N4P; -; . PDBsum 4BS2; -; . PDBsum 4IUF; -; . PDBsum 4Y00; -; . PDBsum 4Y0F; -; . ProteinModelPortal Q13148; -; . SMR Q13148; -; . BioGrid 117003; 330; . DIP DIP-31167N; -; . IntAct Q13148; 36; . MINT MINT-5002768; -; . STRING 9606.ENSP00000240185; -; . ChEMBL CHEMBL2362981; -; . iPTMnet Q13148; -; . PhosphoSitePlus Q13148; -; . SwissPalm Q13148; -; . BioMuta TARDBP; -; . DMDM 20140568; -; . EPD Q13148; -; . MaxQB Q13148; -; . PaxDb Q13148; -; . PeptideAtlas Q13148; -; . PRIDE Q13148; -; . DNASU 23435; -; . Ensembl ENST00000240185; ENSP00000240185; ENSG00000120948. [Q13148-1]; . GeneID 23435; -; . KEGG hsa:23435; -; . UCSC uc001art.4; human. [Q13148-1]; . CTD 23435; -; . DisGeNET 23435; -; . GeneCards TARDBP; -; . GeneReviews TARDBP; -; . HGNC HGNC:11571; TARDBP; . HPA CAB003703; -; . HPA HPA017284; -; . MalaCards TARDBP; -; . MIM 605078; gene; . MIM 612069; phenotype; . neXtProt NX_Q13148; -; . OpenTargets ENSG00000120948; -; . Orphanet 803; Amyotrophic lateral sclerosis; . Orphanet 275872; Frontotemporal dementia with motor neuron disease; . PharmGKB PA36336; -; . eggNOG ENOG410IFJS; Eukaryota; . eggNOG ENOG410ZYQJ; LUCA; . GeneTree ENSGT00850000132362; -; . HOGENOM HOG000254792; -; . HOVERGEN HBG058671; -; . InParanoid Q13148; -; . OMA KHNSSRQ; -; . OrthoDB EOG091G0BJZ; -; . PhylomeDB Q13148; -; . TreeFam TF315657; -; . ChiTaRS TARDBP; human; . EvolutionaryTrace Q13148; -; . GeneWiki TARDBP; -; . GenomeRNAi 23435; -; . PRO PR:Q13148; -; . Proteomes UP000005640; Chromosome 1; . Bgee ENSG00000120948; -; . CleanEx HS_TARDBP; -; . ExpressionAtlas Q13148; baseline and differential; . Genevisible Q13148; HS; . GO GO:0005737; C:cytoplasm; IEA:Ensembl; . GO GO:0035061; C:interchromatin granule; IEA:Ensembl; . GO GO:0016607; C:nuclear speck; IEA:Ensembl; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:LIFEdb; . GO GO:0005726; C:perichromatin fibrils; IEA:Ensembl; . GO GO:0003690; F:double-stranded DNA binding; IDA:BHF-UCL; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0003730; F:mRNA 3'-UTR binding; IDA:BHF-UCL; . GO GO:0000166; F:nucleotide binding; IEA:InterPro; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0003700; F:transcription factor activity; sequence-specific DNA binding; TAS:ProtInc GO GO:0001205; F:transcriptional activator activity; RNA polymerase II distal enhancer sequence-specific binding; IEA:Ensembl GO GO:0070935; P:3'-UTR-mediated mRNA stabilization; IDA:BHF-UCL; . GO GO:0006397; P:mRNA processing; IEA:UniProtKB-KW; . GO GO:0043922; P:negative regulation by host of viral transcription; IDA:BHF-UCL; . GO GO:0010629; P:negative regulation of gene expression; IMP:CACAO; . GO GO:0001933; P:negative regulation of protein phosphorylation; IMP:CACAO; . GO GO:0030264; P:nuclear fragmentation involved in apoptotic nuclear change; IMP:CACAO; . GO GO:0071765; P:nuclear inner membrane organization; IMP:CACAO; . GO GO:0032024; P:positive regulation of insulin secretion; IEA:Ensembl; . GO GO:0051726; P:regulation of cell cycle; IMP:CACAO; . GO GO:0034976; P:response to endoplasmic reticulum stress; IEA:Ensembl; . GO GO:0008380; P:RNA splicing; IDA:BHF-UCL; . GO GO:0006366; P:transcription from RNA polymerase II promoter; TAS:ProtInc; . Gene3D 3.30.70.330; -; 2; . InterPro IPR012677; Nucleotide-bd_a/b_plait; . InterPro IPR000504; RRM_dom; . Pfam PF00076; RRM_1; 2; . SMART SM00360; RRM; 2; . SUPFAM SSF54928; SSF54928; 2; . PROSITE PS50102; RRM; 2; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

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